Buy 4-HO-DBT (4-hydroxy-N) Cas 63065-89-4

Buy 4-HO-DBT (4-hydroxy-N) Cas 63065-89-4

4-HO-DBT, also known as 4-hydroxy-N,N-dibutyltryptamine, is a psychedelic drug of the tryptamine family related to psilocin (4-HO-DMT).^[1] It is taken orally.^[1]

In his book TiHKAL (Tryptamines I Have Known and Loved), Alexander Shulgin reported that a 20 mg dose of 4-HO-DBT orally produced no effects.^[1] However, this compound has subsequently been sold as a “research chemical” and anecdotal reports suggest that at higher doses 4-HO-DBT is indeed an active hallucinogen, although somewhat weaker than other similar tryptamine derivatives.^{[citation needed]}

4-HO-DBT is found either as its crystalline hydrochloride salt or as an oily or crystalline base.

The chemical synthesis of 4-HO-DBT has been described.^[1]

Several different isomers of 4-HO-DBT could be made, including 4-HO-DiBT, 4-HO-DsBT, and 4-HO-DtBT, but of these only the isobutyl isomer 4-HO-DiBT was synthesized by Alexander Shulgin (melting point 152 to 154 °C) and was also found to be inactive at a 20 mg dose.^[1] The serotonin receptor interactions of these isomers have been studied.^[2] 4-HO-DiBT showed 43-fold lower affinity and 4-HO-DsBT 6.5-fold lower affinity for the serotonin 5-HT_2A receptor compared to psilocin (4-HO-DMT).^[2]

4-HO-DBT was first described in the scientific literature by David Repke and colleagues in 1977.^[3] It was subsequently described in further detail by Alexander Shulgin in his 1997 book TiHKAL (Tryptamines I have Known and Loved).^[1]