Buy 4-Methyl-DMT Cas 28289-23-8

Buy 4-Methyl-DMT Cas 28289-23-8

4-Methyl-DMT, or 4-Me-DMT, also known as 4-methyl-N,N-dimethyltryptamine or as 4,N,N-trimethyltryptamine (4,N,N-TMT or 4-TMT), is a serotonin receptor modulator and possible psychedelic drug of the tryptamine family related to dimethyltryptamine (DMT) and psilocin (4-HO-DMT).^[1][2][3]

4-Methyl-DMT was not included nor mentioned in Alexander Shulgin‘s book TiHKAL (Tryptamines I Have Known and Loved).^[4] Its dose in humans is unknown.^[2]

The related drug 4-methyl-AMT has shown mixed findings in terms of hallucinogenic effects in humans and is clearly less potent than α-methyltryptamine (AMT) in such regards.^[4][5][6]

4-Methyl-DMT showed affinity for the serotonin receptors in the isolated rat stomach fundus strip (A₂ = 141 nM).^[1] Its affinity for these receptors was 7-fold higher than that of dimethyltryptamine (DMT), roughly the same as that of psilocin (4-HO-DMT), and about 60% of that of 5-MeO-DMT.^[1][7] However, this assay was subsequently found to be an unreliable predictor of hallucinogenic activity.^[8] The receptor in this tissue may correspond to the serotonin 5-HT_2B receptor.^[9]

In other studies, 4-methyl-DMT was assessed and showed affinity for the serotonin 5-HT_1E receptor (K_i = 470 nM) and for the serotonin 5-HT_1F receptor (K_i = 198 nM).^[3] These affinities were similar to but slightly lower than those of DMT (K_i = 300 nM and 130 nM, respectively).^[3]

Like DMT and 5-MeO-DMT, 4-methyl-DMT fully substituted for the psychedelic drug DOM in rodent drug discrimination tests.^[2] It was a little more than twice as potent as DMT in this assay but was about half as potent as 5-MeO-DMT.^[2] Similarly to diethyltryptamine (DET) and dipropyltryptamine (DPT), 4-methyl-DMT produced behavioral disruption at higher doses.^[2]

The chemical synthesis of 4-methyl-DMT has been described.^[1]

Analogues of 4-methyl-DMT include dimethyltryptamine (DMT), psilocin (4-HO-DMT), 4-fluoro-DMT, 4-MeO-DMT, 4-MeO-DET, 1-methyl-DMT, 2-methyl-DMT, 4-methyl-AMT, 4-methyl-AET, 5-methyl-DMT, 6-methyl-DMT, 7-methyl-DMT, and RS134-49 (4-methyl-THPI), among others.^[4]

4-Methyl-DMT was first described in the scientific literature by Richard Glennon and colleagues by 1983.^[2][1][3]

4-Methyl-DMT is not an explicitly nor implicitly controlled substance in Canada as of 2025.^[10]

4-Methyl-DMT is not an explicitly controlled substance in the United States.^[11] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.