Buy 5-Bromo-DMT Cas 17274-65-6

Buy 5-Bromo-DMT Cas 17274-65-6

5-Bromo-DMT, or 5-Br-DMT, also known as 5-bromo-N,N-dimethyltryptamine or by informal names like sea DMT or SpongeBob DMT^{[dubious – discuss]}, is a psychedelic drug and brominated indole alkaloid of the tryptamine family related to dimethyltryptamine (DMT).^[1][2][3] It is the 5-bromo derivative of DMT.^[1] The drug is naturally occurring in the sponges Smenospongia aurea and Smenospongia echina, as well as in Verongula rigida (0.00142% dry weight) alongside 5,6-dibromo-DMT (0.35% dry weight) and seven other alkaloids.^{[1][4][5][6][7]} It has been encountered as a novel designer drug.^[8][9]

5-Bromo-DMT was only briefly mentioned in Alexander Shulgin‘s book TiHKAL (Tryptamines I Have Known and Loved) and its properties and effects were not described.^[10] Subsequently, the drug has been reported by others to have a dose of 20 to 50 mg smoked and a duration of 15 minutes to 1.5 hours.^[1][8] It is minimally active or inactive orally.^[1] It was described as producing mild psychedelic effects, such as visuals, pronounced tactile effects, and euphoria.^[1][8] 5-Bromo-DMT was said to be similar to low-dose DMT, but also distinct from it.^[1] A 50 mg dose was said to be near the limit of what can be physically inhaled.^[1] However, it was thought that greater exposure to the drug nonetheless might be able to produce stronger effects.^[1] These findings were reported in a Shulgin- or TiHKAL-like style via credible anonymous personal communication with Hamilton Morris and Jason Wallach.^[1]

5-Bromo-DMT is a partial agonist of the serotonin 5-HT_2A receptor, with an affinity (K_i) of 138 nM, an EC₅₀Tooltip half-maximal effective concentration of 77.7 to 3,090 nM, and an E_maxTooltip maximal efficacy of 34 to 100%.^[2][3][11] It also shows affinity for the serotonin 5-HT_1A, 5-HT_2B, and 5-HT_2C receptors and for the serotonin transporter (SERT) (K_i = 16.9 nM, 403 nM, 193 nM, and 971 nM, respectively).^[3] The drug is a weak serotonin 5-HT_1A receptor full agonist (EC₅₀ = 1,810 nM; E_max = 94%) and a very weak serotonin reuptake inhibitor (IC₅₀Tooltip half-maximal inhibitory concentration = 8,055 nM).^[3]

In contrast to 5-fluoro-DMT and 5-chloro-DMT, 5-bromo-DMT failed to significantly produce the head-twitch response, a behavioral proxy of psychedelic effects, in rodents.^{[2][3][12][13]} As such, 5-bromo-DMT would be expected to be non-hallucinogenic in humans.^[2] In addition, 5-bromo-DMT antagonized the head-twitch response induced by 5-fluoro-DMT.^[3] On the other hand, 5-bromo-DMT produced antidepressant-like effects, hypolocomotion or sedative-like effects, and hypothermia in rodents.^{[3][2][1][14]} Moreover, 5-bromo-DMT has been found to produce psychoplastogenic effects.^[3]

The chemical synthesis of 5-bromo-DMT has been described.^[1]

Analogues of 5-bromo-DMT include 5,6-dibromo-DMT, 5-fluoro-DMT, 5-chloro-DMT, bretisilocin (5-fluoro-MET), 5-fluoro-DET, 5-fluoro-AMT, 5-chloro-AMT, BK-5Br-NM-AMT, 5-nitro-DMT, convolutindole A, desformylflustrabromine, and plakohypaphorine, among others.

5-Bromo-DMT was briefly mentioned by Alexander Shulgin in his 1991 book TiHKAL (Tryptamines I Have Known and Loved), but he did not synthesize or test it.^[1][10] Hamilton Morris and Jason Wallach reported the properties and hallucinogenic effects of 5-bromo-DMT in humans in 2013 via publication of credible personal communication with an anonymous “Dr. Osculum”.^[1] 5-Bromo-DMT was described as a novel designer drug by 2020.^[8][9]

5-Bromo-DMT is not a controlled substance in Canada as of 2025.^[15]

5-Bromo-DMT is specifically listed as a controlled drug in Singapore.^[16]

5-Bromo-DMT is not an explicitly controlled substance in the United States.^[17] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.