Buy 5-Fluoro-DMT Cas 22120-36-1

Buy 5-Fluoro-DMT Cas 22120-36-1

5-Fluoro-DMT, or 5-F-DMT, also known as 5-fluoro-N,N-dimethyltryptamine, is a psychedelic drug of the tryptamine family related to dimethyltryptamine (DMT) and to other psychedelic tryptamines like 5-chloro-DMT and 5-bromo-DMT.^[1][2]

5-Fluoro-DMT was not included nor mentioned in Alexander Shulgin‘s book TiHKAL (Tryptamines I Have Known and Loved).^[3]

5-Fluoro-DMT is known to have affinity for and to act as an agonist of the serotonin 5-HT_1A and 5-HT_2A receptors.^[1][4][5] Fluorination of psychedelic tryptamines either reduces or has little effect on serotonin 5-HT_2A and 5-HT_2C receptor affinity or intrinsic activity, although 6-fluoro-DET is inactive as a psychedelic despite acting as a 5-HT_2A agonist (cf. lisuride), while 4-fluoro-5-methoxy-DMT is a much stronger agonist at the serotonin 5-HT_1A receptor than at the serotonin 5-HT_2A receptor.^[6][7]

5-Fluoro-DMT produces a robust head-twitch response in mice, and hence is a putative serotonergic psychedelic.^[8][1][9] In another study however, it failed to substitute for LSD in rodent drug discrimination tests, at least at the assessed doses.^[10] The drug also produces hypolocomotion and hypothermia in rodents.^[1]

Analogues of 5-fluoro-DMT include dimethyltryptamine (DMT), 5-fluorotryptamine (5-fluoro-T), 5-bromo-DMT, 5-chloro-DMT, bretisilocin (5-fluoro-MET), 5-fluoro-DET, 4-fluoro-DMT, 6-fluoro-DMT, 6-fluoro-DET, 4-fluoro-5-methoxy-DMT, 5-fluoro-AMT, 6-fluoro-AMT, and O-4310 (1-iPr-6-F-4-HO-DMT), among others.

5-Fluoro-DMT was first described in the scientific literature by Stephen Szára and colleagues by 1966.^[11]

5-Fluoro-DMT is not an explicitly nor implicitly controlled substance in Canada as of 2025.^[12]

5-Fluoro-DMT is not an explicitly controlled substance in the United States.^[13] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.