Buy Difluoroescaline (DFE) Cas 501700-02-3
Buy Difluoroescaline (DFE) Cas 501700-02-3
Difluoroescaline (DFE), also known as 4-(2,2-difluoroethoxy)-3,5-dimethoxyphenethylamine, is a psychedelic drug of the phenethylamine and scaline families related to mescaline.[1][2][3] It is a difluorinated derivative of escaline.[1][2][3] Its dose range is 40 to 80 mg and its duration is 6 to 12 hours.[1][2][3] The drug’s effects include color enhancement, some closed-eye and open-eye visuals, emotional changes, and some physical discomfort.[1] It acts as a low-potency partial agonist of the serotonin 5-HT2A receptor and also interacts with other serotonin receptors and targets.[3][2] The chemical synthesis of difluoroescaline has been described.[4] Difluoroescaline was first described in the scientific literature by Daniel Trachsel in 2002.[1][2][3][4] Its pharmacology was studied in more detail in 2021.[3] It is not a controlled substance in Canada as of 2025.[5]



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