Buy 4-Thiomescaline (4-TM) Cas 71539-35-0

Buy 4-Thiomescaline (4-TM) Cas 71539-35-0

4-Thiomescaline (4-TM), or simply thiomescaline, also known as 3,5-dimethoxy-4-methylthiophenethylamine, is a psychedelic drug of the phenethylamine and scaline families related to mescaline (3,4,5-trimethoxyphenethylamine).^{[1][3][4][2][5]} It is the analogue of mescaline in which the methoxy group at the 4 position has been replaced with a methylthio group.^[1][3][4][5] The drug is one of two possible thiomescaline (TM) positional isomers, the other being 3-thiomescaline (3-TM).^[1][3][4][5]

In his book PiHKAL (Phenethylamines I Have Known and Loved) and other publications, Alexander Shulgin lists 4-TM’s dose as 20 to 40 mg orally and its duration as 10 to 15 hours.^{[1][3][4][2][5]} Its onset is 30 to 60 minutes.^[1][2] The drug has about 10 times the potency of mescaline.^{[1][3][4][5][6][7][8]} The effects of 4-TM have been reported to include little color enhancement, closed-eye imagery, fantasy, feeling strange, feelings of unreality, seeing reality like a Möbius strip, introspection, insights, lightheadedness, physical uneasiness, tremor, abdominal cramps, walking difficulty, appetite loss, and some tactile numbness.^[1][2][5] Shulgin described it as a “mixed bag of responses”.^[1] It was described as being more similar in its effects to LSD than to mescaline and as being similar in effects to the Aleph series.^[1][2]

The chemical synthesis of 4-TM has been described.^[1][5][2]

4-TM was first synthesized and tested in 1977 and was described in the literature by Shulgin and colleagues in 1978.^[4][2][5] Subsequently, it was described in greater detail by Shulgin in PiHKAL in 1991.^[1]