Buy 2C-Bu Cas 2888537-44-6

Buy 2C-Bu Cas 2888537-44-6

2C-Bu, also known as 4-butyl-2,5-dimethoxyphenethylamine, is a serotonin receptor modulator of the phenethylamine and 2C families.^[1][2] It is the 2C analogue of the DOx derivative DOBU.^[1][3][4]

2C-Bu was not included in Alexander Shulgin‘s book PiHKAL (Phenethylamines I Have Known and Loved) and its properties and effects in humans are unknown.^[3][1]

2C-Bu is a potent and high-efficacy serotonin 5-HT_2A receptor partial agonist, with an EC₅₀Tooltip half-maximal effective concentration of 3.9 to 29 nM and an E_maxTooltip maximal efficacy of 71 to 93%.^[2]

2C-Bu follows 2C-D, 2C-E, and 2C-P in the homologous series of 4-alkylated 2C derivatives.^[1] Higher homologues of 2C-Bu including 2C-Am and 2C-Hx are also known and have been characterized.^[2]

2C-Bu has several notable skeletal isomers, including 2C-iBu, 2C-tBu, and 2C-sBu.^[1][5] 2C-iBu and 2C-tBu are both active and produce hallucinogen-type effects in animals and/or humans.^[6][7][8][5] This is in spite of 2C-tBu being predicted to be inactive^[5] and DOTB (the DOx analogue of 2C-tBu) being inactive as a hallucinogen in animals and humans.^[3][9] 2C-iBu may have reduced hallucinogenic potency than other 2C drugs and is being developed as a potential anti-inflammatory medication.^[7][8]

2C-Bu was said by Daniel Trachsel and colleagues in 2013 to be completely unknown.^[1] Subsequently, the drug was characterized in 2025.^[2]

2C-Bu is a controlled substance in Canada under phenethylamine blanket-ban language.^[10]