Buy TMA-6 Cas 15402-79-6

Buy TMA-6 Cas 15402-79-6

2,4,6-Trimethoxyamphetamine (2,4,6-TMA), also known as TMA-6 or ψ-TMA-2, is a psychedelic drug of the phenethylamine, amphetamine, and Ψ-PEA families.^[1][2][3] It is one of the positional isomers of trimethoxyamphetamine (TMA).^[1][2][3]

In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists TMA-6’s dose as 25 to 50 mg orally and its duration as 12 to 16 hours.^[1] Threshold effects occur at 20 mg, a full hallucinogenic state occurs at 30 to 40 mg, and erratic results have been reported for 40 to 80 mg.^[3] The drug is said to have about 8 to 10 times the potency of mescaline.^[4][5][6]

The effects of TMA-6 have been reported to include ease with concepts and writing, body tingling, walking unsteadiness, thinking difficulty or intoxication, difficulty with tasks, funniness, hilarity, and laughter, difficulty sleeping, inner chill, visual sparkle, stomach queasiness, diarrhea, reduced appetite, fluctuating emotions, personal insights, visuals, colors, and feelings of “energy flow”.^[1] Additional reported effects include enjoyable lightheadedness, euphoria, perceptual distortion, synesthesia, and nausea.^[4][7]

TMA-6 shows affinity for serotonin receptors in rat stomach fundus strips (A₂ = 525 nM) as well as in rat brain membranes (IC₅₀Tooltip half-maximal inhibitory concentration = 25,000 nM).^[2][8][9] In a later study, it showed no affinity for the serotonin 5-HT_1A or dopamine D₂ receptors (K_i = >10,000 nM).^[10] Subsequently, it was reported to be a potent serotonin 5-HT_2A receptor full agonist, with an EC₅₀Tooltip half-maximal effective concentration of 29.2 nM and an E_maxTooltip maximal efficacy of 107%.^[11] The drug was inactive as a monoamine reuptake inhibitor and releasing agent in rat brain synaptosomes (IC₅₀Tooltip half-maximal inhibitory concentration and EC₅₀Tooltip half-maximal effective concentration = >100,000 nM, respectively).^[12][13][14] The drug is a potent monoamine oxidase A (MAO-A) inhibitor, with an IC₅₀Tooltip half-maximal inhibitory concentration of 400 nM.^[15] This is in contrast to TMA (3,4,5-TMA) and TMA-2 (2,4,5-TMA), which are inactive in this regard.^[15]

TMA-6 fully substitutes for the psychedelic drugs DOM and 5-MeO-DMT in rodent drug discrimination tests.^[2][16][17] It also partially substitutes for dextroamphetamine in rodent drug discrimination tests.^[2][18]

The chemical synthesis of TMA-6 has been described.^[1]

A number of analogues of TMA-6 with a 2,4,6- substitution pattern have been described, such as Ψ-DOM and ψ-2C-T-4, among others.^{[1][19][20][21][22]} Alexander Shulgin only limitedly explored the 2,4,6- substitution pattern.^[23][21]

TMA-6 was first described in the scientific literature by 1954.^[2][3][24] Alexander Shulgin discovered its psychedelic effects in 1964^[3] and first described its hallucinogenic effects in the literature in 1969, where he stated its potency relative to mescaline and noted that these findings were previously unpublished.^{[25][5][26][27]} Shulgin subsequently gave the drug the name TMA-6 in 1970.^[26] He more thoroughly described TMA-6 in PiHKAL in 1991.^[1] The drug was encountered as a novel designer drug in Europe in 2009.^[28]

TMA-6 is a controlled substance in Canada under phenethylamine blanket-ban language.^[29]

As a positional isomer of TMA, TMA-6 is a Schedule I controlled substance in the United States.^[30] [2]