Buy F-17475 Cas 1612885-86-5
Buy F-17475 Cas 1612885-86-5
F-17475 is an NMDA receptor antagonist described as an analgesic, which was under development for the treatment of postoperative pain but was never marketed.[1]
The drug shows similar affinity for the NMDA receptor as ketamine (Ki = 0.74 and 1.05 μM, respectively).[1] It shows analgesic effects in rodents, with about twice the potency of ketamine, and potentiates morphine-induced analgesia.[1] F-17475 substitutes for ketamine in rodent drug discrimination tests, suggesting that it may have dissociative hallucinogen effects in humans.[1] However, F-17475 showed a greater margin of analgesic to dissociative-like effects than ketamine in rodents.[1]
F-17475 was first described in the patent literature by 2012, developed by researchers at Pierre Fabre. The m-chloro derivative is slightly more potent, up to 10x stronger than ketamine, but had a less favorable side effect profile in animal tests.[2]
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