Buy Delta-9-tetrahydrocannabiphorol (THCP) Cas 54763-99-4

Buy Delta-9-tetrahydrocannabiphorol (THCP) Cas 54763-99-4

Tetrahydrocannabiphorol (THCP) is a potent phytocannabinoid, a CB₁ and CB₂ receptor agonist which was known as a synthetic homologue of tetrahydrocannabinol (THC),^[1] but for the first time in 2019 was isolated as a trace natural product from Cannabis sativa.^[2]^[3]

THCP is structurally similar to Δ⁹-THC, the main active component of cannabis, but with the pentyl side chain extended to heptyl. Since it has a longer side chain, its cannabinoid effects are “far higher than Δ⁹-THC itself.” Tetrahydrocannabiphorol has a reported binding affinity of 1.2 nM at CB₁, approximately 33 times that of Δ⁹-THC (40 nM at CB₁), however this does not mean it’s 33x stronger per milligram.^[4]

THCP was studied by Roger Adams as early as 1942.^[5]

Isomers

Delta-3-THCP

The Δ³/Δ^6a(10a) isomer Δ³-THCP was synthesised in 1941, and was found to have around the same potency as Δ³-THC, unlike the hexyl homologue parahexyl which was significantly stronger.^[6]

Delta-8-THCP

The Δ⁸ isomer is also known as a synthetic cannabinoid under the code name JWH-091.^[7]^[8] It’s unconfirmed whether or not JWH-091 is found naturally in cannabis plants.^[9] JWH-091 has approximately double the binding affinity at the CB₁ receptor (22 nM ± 3.9 nM) in comparison to Δ⁹-THC (40.7 nM ± 1.7 nM) or Δ⁸-THC (44 nM ± 12 nM),^[8] but appears significantly lower in vitro than the binding activity of Δ⁹-THCP (K_i = 1.2 nM)^[4]

Natural cannabis occurrence

The Δ⁹ isomer of THCP occurs naturally in cannabis plants, but in very small amounts. A 2021 study reported the content of Δ⁹-THCP ranging from 0.0023% to 0.0136% (w/w) (approximately 0.02–0.13 mg/g biomass) without correlation to THC percentage in Δ⁹-THC-dominant strains of cannabis; that study failed to detect THCP in CBD-dominant strains.^[2]^[10]

Δ8-THC-DMH
Nabilone
Hexahydrocannabiphorol (HHCP)
1,2-Didehydro-3-oxo-THCO
Delta-8-THC
Parahexyl
Perrottetinene
Tetrahydrocannabivarin (THCV)
Tetrahydrocannabutol
Tetrahydrocannabihexol (THCH)
THCP-O-acetate
Cannabidiphorol (CBDP)
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Tetrahydrocannabiphorol (THCP) is a phytocannabinoid.

Biological Activity I Assay Protocols (From Reference)

References	[1]. A novel phytocannabinoid isolated from Cannabis sativa L. with an in vivo cannabimimetic activity higher than Δ9-tetrahydrocannabinol: Δ9-Tetrahydrocannabiphorol. Sci Rep. 2019 Dec 30;9(1):20335.
Additional Infomation	3-Heptyl-delta(1)-tetrahydrocannabinol is the (6aR-trans) isomer.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Physicochemical Properties

Molecular Formula	C23H34O2
Molecular Weight	342.51
Exact Mass	342.256
CAS #	54763-99-4
PubChem CID	6453074
Appearance	Typically exists as solids at room temperature
LogP	6.516
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	6
Heavy Atom Count	25
Complexity	467
Defined Atom Stereocenter Count	2
SMILES	CCCCCCCC1=CC(=C2C3C=C(CCC3C(OC2=C1)(C)C)C)O
InChi Key	OJTMRZHYTZMJKX-RTBURBONSA-N
InChi Code	InChI=1S/C23H34O2/c1-5-6-7-8-9-10-17-14-20(24)22-18-13-16(2)11-12-19(18)23(3,4)25-21(22)15-17/h13-15,18-19,24H,5-12H2,1-4H3/t18-,19-/m1/s1
Chemical Name	(6aR,10aR)-3-heptyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydrobenzo[c]chromen-1-ol
Synonyms	THCP
HS Tariff Code	2934.99.9001
Storage	Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Solubility Data

Solubility (In Vitro)	May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples
Solubility (In Vivo)	Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples. Injection Formulations (e.g. IP/IV/IM/SC) Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline) Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution. Injection Formulation 2:* DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil) Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals). View More Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)] Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Injection Formulation 5:* 2-Hydroxypropyl-β-cyclodextrin : Saline = 50 : 50 (i.e. 500 μL 2-Hydroxypropyl-β-cyclodextrin → 500 μL Saline) Injection Formulation 6: DMSO : PEG300 : castor oil : Saline = 5 : 10 : 20 : 65 (i.e. 50 μL DMSO → 100 μLPEG300 → 200 μL castor oil → 650 μL Saline) Injection Formulation 7: Ethanol : Cremophor : Saline = 10： 10 : 80 (i.e. 100 μL Ethanol → 100 μL Cremophor → 800 μL Saline) Injection Formulation 8: Dissolve in Cremophor/Ethanol (50 : 50), then diluted by Saline Injection Formulation 9: EtOH : Corn oil = 10 : 90 (i.e. 100 μL EtOH → 900 μL Corn oil) Injection Formulation 10: EtOH : PEG300：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL EtOH → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline) Oral Formulations Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium) Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals). View More Oral Formulation 3: Dissolved in PEG400 Oral Formulation 4: Suspend in 0.2% Carboxymethyl cellulose Oral Formulation 5: Dissolve in 0.25% Tween 80 and 0.5% Carboxymethyl cellulose Oral Formulation 6: Mixing with food powders Note: Please be aware that the above formulations are for reference only. InvivoChem strongly recommends customers to read literature methods/protocols carefully before determining which formulation you should use for in vivo studies, as different compounds have different solubility properties and have to be formulated differently. (Please use freshly prepared in vivo formulations for optimal results.)

Solubility (In Vitro)

May dissolve in DMSO (in most cases), if not, try other solvents such as H2O, Ethanol, or DMF with a minute amount of products to avoid loss of samples

Solubility (In Vivo)

Note: Listed below are some common formulations that may be used to formulate products with low water solubility (e.g. < 1 mg/mL), you may test these formulations using a minute amount of products to avoid loss of samples.

Injection Formulations
(e.g. IP/IV/IM/SC)

Injection Formulation 1: DMSO : Tween 80： Saline = 10 : 5 : 85 (i.e. 100 μL DMSO stock solution → 50 μL Tween 80 → 850 μL Saline)
*Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH ₂ O to obtain a clear solution.
Injection Formulation 2: DMSO : PEG300 ：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL DMSO → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline)
Injection Formulation 3: DMSO : Corn oil = 10 : 90 (i.e. 100 μL DMSO → 900 μL Corn oil)
Example: Take the Injection Formulation 3 (DMSO : Corn oil = 10 : 90) as an example, if 1 mL of 2.5 mg/mL working solution is to be prepared, you can take 100 μL 25 mg/mL DMSO stock solution and add to 900 μL corn oil, mix well to obtain a clear or suspension solution (2.5 mg/mL, ready for use in animals).

View More

Injection Formulation 4: DMSO : 20% SBE-β-CD in saline = 10 : 90 [i.e. 100 μL DMSO → 900 μL (20% SBE-β-CD in saline)]
*Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.
Injection Formulation 5: 2-Hydroxypropyl-β-cyclodextrin : Saline = 50 : 50 (i.e. 500 μL 2-Hydroxypropyl-β-cyclodextrin → 500 μL Saline)
Injection Formulation 6: DMSO : PEG300 : castor oil : Saline = 5 : 10 : 20 : 65 (i.e. 50 μL DMSO → 100 μLPEG300 → 200 μL castor oil → 650 μL Saline)
Injection Formulation 7: Ethanol : Cremophor : Saline = 10： 10 : 80 (i.e. 100 μL Ethanol → 100 μL Cremophor → 800 μL Saline)
Injection Formulation 8: Dissolve in Cremophor/Ethanol (50 : 50), then diluted by Saline
Injection Formulation 9: EtOH : Corn oil = 10 : 90 (i.e. 100 μL EtOH → 900 μL Corn oil)
Injection Formulation 10: EtOH : PEG300：Tween 80 : Saline = 10 : 40 : 5 : 45 (i.e. 100 μL EtOH → 400 μLPEG300 → 50 μL Tween 80 → 450 μL Saline)

Oral Formulations

Oral Formulation 1: Suspend in 0.5% CMC Na (carboxymethylcellulose sodium)
Oral Formulation 2: Suspend in 0.5% Carboxymethyl cellulose
Example: Take the Oral Formulation 1 (Suspend in 0.5% CMC Na) as an example, if 100 mL of 2.5 mg/mL working solution is to be prepared, you can first prepare 0.5% CMC Na solution by measuring 0.5 g CMC Na and dissolve it in 100 mL ddH2O to obtain a clear solution; then add 250 mg of the product to 100 mL 0.5% CMC Na solution, to make the suspension solution (2.5 mg/mL, ready for use in animals).

View More

Oral Formulation 3: Dissolved in PEG400
Oral Formulation 4: Suspend in 0.2% Carboxymethyl cellulose
Oral Formulation 5: Dissolve in 0.25% Tween 80 and 0.5% Carboxymethyl cellulose
Oral Formulation 6: Mixing with food powders

Note: Please be aware that the above formulations are for reference only. InvivoChem strongly recommends customers to read literature methods/protocols carefully before determining which formulation you should use for in vivo studies, as different compounds have different solubility properties and have to be formulated differently.

(Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.9196 mL	14.5981 mL	29.1962 mL
	5 mM	0.5839 mL	2.9196 mL	5.8392 mL
	10 mM	0.2920 mL	1.4598 mL	2.9196 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.

Product Details

CasNo： 54763-99-4

Molecular Formula： C23H34 O2

Good Supplier Sale High Quality Tetrahydrocannabiphorol 54763-99-4

54763-99-4 Name
Name	Tetrahydrocannabiphorol
Synonym	3-heptyl-delta(1)-tetrahydrocannabinol;6H-Dibenzo[b,d]pyran-1-ol, 3-heptyl-6a,7,8,10a-tetrahydro-6,6,9-trimethyl-, (6aR-trans)- (9CI);Δ9-THCP;Tetrahydrocannabiphorol (THCP)

54763-99-4 Chemical & Physical Properties
Molecular Formula	C23H34O2
Molecular Weight	342.51500
PSA	29.46000
LogP	6.51600
Exact Mass	342.25600

Tetrahydrocannabiphorol 54763-99-4 Good Supplier

Tetrahydrocannabiphorol (THCP) is a potent phytocannabinoid, a CB1 and CB2 agonist which was known as a synthetic homologue of THC. THCP, which is short for tetrahydrocannabiphorol and scientifically known as (-)-Trans-Δ9-tetrahydrocannabiphorol, is a natural cannabinoid found in the cannabis plant but in super low traces. It takes the #1 spot for the strongest natural cannabinoid ever discovered.

InChI:InChI=1/C23H34O2/c1-5-6-7-8-9-10-17-14-20(24)22-18-13-16(2)11-12-19(18)23(3,4)25-21(22)15-17/h13-15,18-19,24H,5-12H2,1-4H3/t18-,19-/m1/s1

54763-99-4 Relevant articles

(−)-trans-Δ9-Tetrahydrocannabiphorol Content of Cannabis sativa Inflorescence from Various Chemotypes

J Bueno, EA Greenbaum

Journal of Natural Products, 2021, 84, 2, 531–536

The (−)-trans-Δ9-tetrahydrocannabiphorol (Δ9-THCP, 1) content of the inflorescence from six Cannabis sativa chemotypes, including 14 plants of distinct genotypes, and two extracts was determined quantitatively via high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). (−)-trans-Δ9‑Tetrahydrocannabiphorol Content of Cannabis sativa Inflorescence from Various Chemotypes.

54763-99-4 Process route

5-heptyl-2-((1S,6S)-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-enyl)benzene-1,3-diol

54763-99-4

(6aS,10aS)-3-he

delta9-Tetrahydrocannabiphorol (delta9-THCP) solution CAS

This certified Snap-N-Spike^® solution is suitable as starting material in preparation of calibrators or controls for a variety of LC/MS or GC/MS applications …

Delta-9-tetrahydrocannabiphorol (THCP, CAS 54763-99-4) is available for purchase strictly as an analytical reference standard, certified reference material (CRM), or for research and forensic use through chemical supply and scientific vendors.

Cayman Chemical +2

Where to Buy THCP (CAS 54763-99-4)

Δ9-THCP (Alt. Batch CRM): A Certified Reference Material. CAS Number: 54763-99-4. Synonyms: Δ9-Tetrahydrocannabiphorol, Δ9-THC-C7, Δ9-THC-heptyl.

US$194.00

Tetrahydrocannabiphorol (THCP) | Phytocannabinoid

THCP). Tetrahydrocannabiphorol (THCP) is a phytocannabinoid. For research use only. We do not sell to patients. CAS No.: 54763-99-4; Formula: C23H34O2 …Read more

Delta9-THCP (CRM) [A 1 mg/ml solution in acetonitrile]

Standards, LC, Delta-9-Tetrahydrocannabiphorol (THCP) …

Delta9-THCP (CRM) | CAS 54763-99-4 | Cayman Chemical

Delta9-THCP (CRM) (Cay-33691) is a certified reference material categorized as a phytocannabinoid. Delta9-THCP has been found in Cannabis.

Tetrahydrocannabiphorol

delta9-Tetrahydrocannabiphorol (delta9-THCP) solution …

delta9-Tetrahydrocannabiphorol (delta9-THCP) solution 1 mg/mL in methanol, certified reference material, ampule of 1 mL, Cerilliant®; CAS Number: 54763-99-4 …

Tetrahydrocannabiphorol (THCP) 100 µg/mL in Acetonitrile …

Tetrahydrocannabiphorol (THCP) 100 µg/mL in Acetonitrile, CAS # 54763-99-4, 1 mLThis item requires review before shipping. Additional charges may be …

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Tetrahydrocannabiphorol (THCP) 100 µg/mL in Acetonitrile, CAS # 54763-99-4, 1 mL, Non-Returnable, Non-Refundable

Buy Delta-9-tetrahydrocannabiphorol (THCP) Cas 54763-99-4

Isomers

Delta-3-THCP

Delta-8-THCP

Natural cannabis occurrence

See also

Product Details

Good Supplier Sale High Quality Tetrahydrocannabiphorol 54763-99-4

Tetrahydrocannabiphorol 54763-99-4 Good Supplier

54763-99-4 Relevant articles

(−)-trans-Δ9-Tetrahydrocannabiphorol Content of Cannabis sativa Inflorescence from Various Chemotypes

J Bueno, EA Greenbaum

Journal of Natural Products, 2021, 84, 2, 531–536

54763-99-4 Process route

delta9-Tetrahydrocannabiphorol (delta9-THCP) solution CAS

Tetrahydrocannabiphorol (THCP) | Phytocannabinoid

Delta9-THCP (CRM) [A 1 mg/ml solution in acetonitrile]

Standards, LC, Delta-9-Tetrahydrocannabiphorol (THCP) …

Delta9-THCP (CRM) | CAS 54763-99-4 | Cayman Chemical

Tetrahydrocannabiphorol

delta9-Tetrahydrocannabiphorol (delta9-THCP) solution …

Tetrahydrocannabiphorol (THCP) 100 µg/mL in Acetonitrile …

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Buy Delta-9-tetrahydrocannabiphorol (THCP) Cas 54763-99-4

Tetrahydrocannabiphorol (THCP) 100 µg/mL in Acetonitrile, CAS # 54763-99-4, 1 mL, Non-Returnable, Non-Refundable

Buy Delta-9-tetrahydrocannabiphorol (THCP) Cas 54763-99-4

Isomers

Delta-3-THCP

Delta-8-THCP

Natural cannabis occurrence

See also

delta9-Tetrahydrocannabiphorol (delta9-THCP) solution CAS

Tetrahydrocannabiphorol (THCP) | Phytocannabinoid

Delta9-THCP (CRM) [A 1 mg/ml solution in acetonitrile]

Standards, LC, Delta-9-Tetrahydrocannabiphorol (THCP) …

Delta9-THCP (CRM) | CAS 54763-99-4 | Cayman Chemical

Tetrahydrocannabiphorol

delta9-Tetrahydrocannabiphorol (delta9-THCP) solution …

Tetrahydrocannabiphorol (THCP) 100 µg/mL in Acetonitrile …

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