Buy 5-MeO-MET Cas 16977-53-0

Buy 5-MeO-MET Cas 16977-53-0

5-MeO-MET, also known as 5-methoxy-N-methyl-N-ethyltryptamine, is a serotonin receptor modulator, putative serotonergic psychedelic, and relatively rare designer drug of the tryptamine family related to psychedelic drugs like methylethyltryptamine (MET) and 5-MeO-DMT.^{[2][3][4][5][6]}

5-MeO-MET was not included nor mentioned in Alexander Shulgin‘s book TiHKAL (Tryptamines I Have Known and Loved).^[1] Relatedly, its properties, such as dose and duration, and its effects were not described.^[1]

Early studies found 5-MeO-MET to be more potent in animal behavioral tests than 5-MeO-DMT.^[3][7] Subsequent studies confirmed that 5-MeO-MET interacts with serotonin receptors similarly to other psychedelic tryptamines.^[8][9] A more modern study found that 5-MeO-MET is a potent serotonin 5-HT_1A receptor ligand and serotonin 5-HT_2A receptor agonist and produces the head-twitch response, a behavioral proxy of psychedelics, in rodents.^[2][10] Its activities were of similar potency as 5-MeO-DMT.^[2]

Analogues of 5-MeO-MET include methylethyltryptamine (MET), 4-HO-MET (metocin), 4-AcO-MET (metacetin), 4-PrO-MET, 5-HO-MET, bretisilocin (5-fluoro-MET), 7F-5-MeO-MET, 5-MeO-DMT, 5-MeO-DET, 5-MeO-MPT, 5-MeO-EPT, 5-MeO-MALT, and 5-MeO-MiPT, among others.

5-MeO-MET was first synthesized and limitedly studied in the 1960s.^[3][7][8] The drug was first identified on the illicit market in June 2012 in Sweden.^[11] It was made illegal in Norway in 2013.^[12]

5-MeO-MET is not a controlled substance in Canada as of 2025.^[13]

5-MeO-MET is a controlled substance in Sweden.^[14]

5-MeO-MET is not an explicitly controlled substance in the United States.^[15] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.