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Bromo-DragonFLY, also known as 3C-Bromo-Dragonfly or DOB-Dragonfly, is a psychedelic drug of the phenethylamineDOx, and FLY families.[1][5] It is taken orally.[1][2] The drug has a delayed onset of up to 6 hours and a very long duration of up to 1 to 3 days.[1][2]

Side effects of Bromo-DragonFLY include nausea and vomitingheadachetachycardiahypertensionanxietypanic attackspupil dilationconvulsions and vasoconstriction, among others.[1] The drug acts as an agonist of the serotonin 5-HT2 receptors, including the serotonin 5-HT2A5-HT2B, and 5-HT2C receptors.[1][6][7] It is also a potent monoamine oxidase A (MAO-A) inhibitor.[8]

Bromo-DragonFLY was first described in the scientific literature by David E. Nichols and colleagues in 1998.[1][6] It was encountered as a novel designer drug in 2006.[9] The drug has been associated with an unusually high degree of toxicity and numerous hospitalizations and fatalities.[1] It has become a controlled substance in various countries in the world.[1]

Use and effects

Bromo-DragonFLY was not included nor mentioned in Alexander Shulgin‘s 1991 book PiHKAL (Phenethylamines I Have Known and Loved) as it had not yet been discovered.[10] However, he subsequently described it in his 2011 book The Shulgin Index, Volume One: Psychedelic Phenethylamines and Related Compounds.[11] The dose range of Bromo-DragonFLY is not precisely known, but typical doses are in the range of 100 to 1,000 μg orally.[1][2][3][12] However, a death has been reported at approximately 700 μg Bromo-DragonFLY.[12] Its onset can be delayed by up to 6 hours and its duration is in the range of 12 to 24 hours for many users, but can be up to 2 to 3 days.[2][3][1] The drug’s effects include profound hallucinations and visual distortions, sound alterations, a sense of connection or belonging with other realities, a sense of peace and well-being, emotional stimulation, and meeting with entities.[1]

Side effects

The side effects of Bromo-DragonFLY have been described.[1]

Overdose and toxicity

4BDF Bromo Dragonfly powder. The pink color is most likely due to an impurity. The color of pure Bromo Dragonfly BDF is usually white to off-white.[citation needed]

The toxicity of Bromo-DragonFLY appears to be fairly high for humans, with reports of at least five deaths believed to have resulted from Bromo-DragonFLY in Norway,[13] Sweden,[14][15] Denmark,[16][17] Finland[18] and the United States.

Laboratory testing has confirmed that in October 2009, a batch of Bromo-DragonFLY was distributed, mislabeled as the related compound 2C-B-FLY, which is around 20 times less potent than BDF by weight. This mistake is believed to have contributed to several lethal overdoses and additional hospitalizations. The batch implicated in these deaths also contained significant synthesis impurities, which may have contributed to the toxicity.[19]

Vasoconstrictive action resulting from severe overdose of Bromo-DragonFLY is known to have caused tissue necrosis of the extremities in at least one case. In September 2007, a 35-year-old Swedish male required amputation of the front part of his feet and several fingers on one hand after taking a massive (but unknown) overdose; reportedly, the compound acted as a long-acting efficacious vasoconstrictor, leading to necrosis and gangrene which became apparent several weeks after the overdose occurred. Treatment was of limited efficacy in this case, although tolazoline is reportedly an effective treatment where available.[20][21]

Overdose-associated disturbing experiences and health problems have been described. One case in 2008 in England involved inhalation of vomit, causing nearly fatal asphyxia.[22] Seizures have also been reported.[23]

On October 3, 2009, a 22-year-old male from Copenhagen died after ingesting Bromo-DragonFLY. His friend described the trip saying, “It was like being dragged to hell and back again. Many times. It is the most evil [thing] I’ve ever tried. It lasted an eternity.”[24]

On May 7, 2011, in the United States, two young adults died after overdosing on Bromo-DragonFLY, which they thought was 2C-E, and several others were hospitalized during the same incident. Because they took a dosage appropriate for 2C-E, those who took the drug received, in some cases, 100 times the normal dose. Both deaths followed seizures, vomiting blood, and terrifying hallucinations.[25]

Interactions

Pharmacology

Pharmacodynamics

Bromo-DragonFLY has very high affinity at the serotonin 5-HT2A (Ki = 0.04 nM) and 5-HT2C receptors (Ki = 0.02 nM), along with moderate affinity for the 5-HT2B receptor (Ki = 0.19 nM).[6][26] It is a potent full agonist of these three receptors.[7] Bromo-DragonFLY is also a potent monoamine oxidase A (MAO-A) inhibitor, which may contribute to its risks.[8] The comprehensive receptor interactions of Bromo-DragonFLY have been reported.[27]

Chemistry

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