Buy 5-MeO-DMT-d4 Cas 66521-37-7
Buy 5-MeO-DMT-d4 Cas 66521-37-7
5-MeO-DMT-d4, also known as α,α,β,β-tetradeutero-5-MeO-DMT, is a serotonin receptor modulator and putative psychedelic drug of the tryptamine and 5-methoxytryptamine families related to 5-MeO-DMT.[1][2][3] It is the isotopologue of 5-MeO-DMT in which the hydrogen atoms at the α and β positions have been replaced with the deuterium isotopes.[1][3]
Pharmacology
5-MeO-DMT-d4 shows similar affinities for serotonin receptors and other targets as 5-MeO-DMT.[3] However, the drug is thought to be much more resistant to metabolism by monoamine oxidase (MAO) than 5-MeO-DMT, which in turn may result in greater potency and/or a longer duration.[1][3] In addition, it may result in the drug becoming orally active, though this remains to be studied.[1] It is known that monoamine oxidase inhibitors (MAOIs) with 5-MeO-DMT increase brain exposure to 5-MeO-DMT by approximately 20-fold in animals.[2][4] 5-MeO-DMT-d4 showed similar effects on locomotor activity in rodents as a combination of 5-MeO-DMT and a MAOI.[2][3]
Chemistry
Synthesis
The chemical synthesis of 5-MeO-DMT-d4 has been described.[5]
History
5-MeO-DMT-d4 was first described in the scientific literature by 1977.[6] Subsequently, it was described in greater detail by Adam Halberstadt and David E. Nichols and colleagues in 2012.[1][3] The study of 5-MeO-DMT-d4 was preceded by that of DMT-d4 which was described in the 1980s.[1][3][7][8]
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