AB-CHMINACA is an indazole-based synthetic cannabinoid. It is a potent agonist of the CB₁ receptor (K_i = 0.78 nM) and CB₂ receptor (K_i = 0.45 nM) and fully substitutes for Δ⁹-THC in rat discrimination studies, while being 16x more potent.^[3][4] Continuing the trend seen in other cannabinoids of this generation, such as AB-FUBINACA and AB-PINACA, it contains a valine amino acid amide residue as part of its structure, where older cannabinoids contained a naphthyl or adamantane residue.

There have been a number of reported cases of seizures, deaths, and psychotic episodes in relation to this synthetic cannabinoid.^{[5][6][7][8][9][10][11]}

In 2015, AB-CHMINACA became a Schedule I controlled substance in the United States.^[12]

AB-CHMINACA is an Anlage II controlled substance in Germany as of May 2015.^[13]

As of October 2015 AB-CHMINACA is a controlled substance in China.^[14]

AB-CHMINACA is illegal in Switzerland as of December 2015.^[15]

AB-CHMINACA is an illegal substance in Russian Federation.

1. Buy AB-Chminaca

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   AB-CHMINACA (CAS 1185887-21-1) is a high-purity indazole-based synthetic cannabinoid certified reference material for forensic and clinical toxicology . With a molecular formula of C20H28N4O2 and a molecular weight of 356.5 g/mol, this white crystalline powder is soluble in DMSO and ethanol for analytical workflows . It is intended for LC-MS/MS method development, calibration, and confirmatory analysis of synthetic cannabinoids in forensic toxicology and urine drug testing applications .

   Key Points

   • Synthetic cannabinoid (indazole-3-carboxamide) certified reference material

   • Supplied as high-purity crystalline powder

   • Molecular formula: C20H28N4O2

   • CAS number: 1185887-21-1

   • Soluble in DMSO and ethanol for analytical workflows 

   • Suitable for LC-MS/MS calibration and validation

   • Intended exclusively for forensic toxicology and analytical research

   ⚠️ DISCLAIMER:
   This product is sold strictly for laboratory and research purposes only. It is NOT intended for human or veterinary consumption, diagnostic use, or any application involving living organisms. All customers must be qualified and trained laboratory professionals. Buyer assumes all responsibility for safe handling, storage, and legal compliance in accordance with their local, state, and federal regulations. Always use appropriate personal protective equipment (PPE) and work within a properly ventilated fume hood.

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   Overview

   AB-CHMINACA is a synthetic cannabinoid belonging to the indazole-3-carboxamide class of compounds, first reported in 2013 as a substance found in herbal “Spice” products. This product is supplied as a high-purity crystalline powder for use as an analytical reference standard in forensic and clinical toxicology laboratories. As a potent agonist of the central CB1 receptor, it serves as an essential reference material for the identification and quantification of indazole-based synthetic cannabinoids in seized materials and biological specimens .

   Chemical & Physical Properties

   Parameter	Value / Description
   Chemical name	N-[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]-1-(cyclohexylmethyl)indazole-3-carboxamide
   Common product name	AB-CHMINACA Powder
   Class	Synthetic Cannabinoid (Indazole-3-carboxamide)
   CAS number	1185887-21-1
   Molecular formula	C20H28N4O2
   Molecular weight	Approx. 356.5 g/mol
   Typical salt form	Free base
   Appearance	White to off-white crystalline powder
   Typical solubility	Soluble in DMSO, ethanol, and DMF for analytical preparation
   Typical state	Powder/Crystalline Solid

   The material typically presents as a white to off-white crystalline powder. For analytical preparation, stock solutions are commonly prepared in DMSO, ethanol, or DMF, making it suitable for LC-MS/MS workflows . The compound features a valinamide side chain and a cyclohexylmethyl substituent on the indazole nitrogen, which distinguishes it from related analogs such as ADB-CHMINACA .

   Primary Research Applications

   AB-CHMINACA is primarily utilized as a certified reference material for the identification and quantification of synthetic cannabinoids in forensic toxicology and clinical research . Its applications include method development and validation for LC-MS/MS, as well as confirmatory analysis of biological specimens in urine drug testing and seized material analysis. The compound undergoes extensive Phase I metabolism, with hydroxylated metabolites serving as key urinary biomarkers for consumption verification . Deuterated internal standards, such as AB-CHMINACA-d4, are available for accurate quantification via isotope dilution mass spectrometry . Certified reference materials are manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards .

   Storage & Stability

   Condition	Recommendation
   Temperature	Store at -20°C for long-term stability
   Light exposure	Protect from direct light
   Moisture control	Keep container tightly sealed; store desiccated
   Handling	Use PPE; handle in a fume hood; maintain controlled substance security

   For optimal stability, the product should be stored in a freezer in a tightly sealed container . Certified reference material solutions should be handled promptly after opening to maintain accurate concentration. Stock solutions can be stored below -20°C for several months . Researchers must adhere to standard safe handling practices for hazardous chemicals and maintain appropriate security for controlled substances.

   Closing Statement

   This high-purity certified reference material is intended exclusively for in vitro laboratory use in forensic and analytical research. Researchers should consult the Certificate of Analysis (COA) for specific lot data and certified purity values. All handling must be performed within a properly controlled professional laboratory environment, and users must ensure compliance with all local and federal regulations regarding synthetic cannabinoids.

   ⚠️ DISCLAIMER:
   This product is sold strictly for laboratory and research purposes only. It is NOT intended for human or veterinary consumption, diagnostic use, or any application involving living organisms. All customers must be qualified and trained laboratory professionals. Buyer assumes all responsibility for safe handling, storage, and legal compliance in accordance with their local, state, and federal regulations. Always use appropriate personal protective equipment (PPE) and work within a properly ventilated fume hood

   Buy APINACA (AKB48) – High purity research chemical (purity ≥98%)

   Buy APINACA (AKB48) online – Highly Pure Synthetic Cannabinoid for Scientific Research

   APINACA (AKB48) is a highly refined synthetic cannabinoidResearch chemical from the class of Indazole derivatives. With one HPLC verified purity ≥98 % APINACA is a reference standard for scientific, analytical and forensic investigations. The compound is used in research laboratories to investigate Cannabinoid receptors (CB1 and CB2) used for the development and validation of modern analytical methods.

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   Product overview

   Characteristics	Details
   Product name	APINACA (AKB48)
   Chemical name	N-(1-Adamantyl)-1-pentyl-1H-indazole-3-carbamide
   CAS number	1345973-53-6
   Summary formula	C23H31N3O
   Molar mass	365,51 g/mol
   Purity	≥ 98 % (HPLC verified)
   Form	Powder or solution (subject to availability)
   Chemical class	Synthetic cannabinoid (indazole derivative)
   Purpose	Only for research, analysis and forensics

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   What is APINACA (AKB48)?

   APINACA, also under the name AKB48 is a synthetic cannabinoid receptor agonist with high affinity to the CB1 and CB2 receptors. The compound was originally developed for scientific studies of the endocannabinoid system and later used as a reference substance for pharmacological and analytical research.

   Due to its defined chemical properties, APINACA is ideal for laboratory applications such as:

   • Receptor binding studies
   • Pharmacological research
   • Toxicological studies
   • Forensic analyses
   • Method development and validation
   • Reference standard for analytical procedures

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   High-purity APINACA (AKB48) for professional laboratories

   RChemMart delivers High-purity APINACA (AKB48) with Purity of at least 98 %. Each batch is tested to strict quality standards and is suitable for scientific research projects and analytical applications.

   Our research chemicals are carefully packaged to ensure the best possible product quality and stability during storage and shipping.

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   Typical research applications

   APINACA (AKB48) is often used for:

   • Scientific cannabinoid research
   • Investigation of CB1 and CB2 receptors
   • Pharmacological studies
   • Forensic reference analyses
   • Toxicological studies
   • LC-MS/MS analyses
   • GC-MS analyses
   • Development of analytical methods of detection
   • Quality control in research laboratories

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   Product advantages

   ✅ Purity ≥98 % (tested for HPLC)

   ✅ High quality research chemical

   ✅ Suitable as analytical reference standard

   ✅ Ideal for LC-MS/MS, GC-MS and other laboratory methods

   ✅ Laboratory tested quality

   ✅ Professional and safe packaging

   ✅ Discreet shipping within Europe

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   Important precautionary statement

   APINACA (AKB48) is exclusively for scientific research, laboratory analysis and forensic investigations.

   Not suitable for human or animal consumption.

   This product may only be used by qualified facilities and professionals in controlled laboratory environments.

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   Storage

   For optimal stability, APINACA (AKB48) should:

   • are stored cool and dry,
   • are protected against moisture,
   • are kept protected from light;
   • stored exclusively in the original container.

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   Legal notice

   The legal classification of APINACA (AKB48) It varies by country and by legal system. In many countries, including several EU member states, the US and the UK, the substance is subject to legal restrictions or control measures.

   Buyers are themselves responsible for informing themselves about the applicable national and international regulations before ordering, importing, owning or using them.

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   RChemMart offers high-quality research chemicals to scientific institutions, analytical laboratories and forensic institutes. Our focus is on Tested quality, high purity, discreet shipping and Reliable customer serviceso that your research projects can build on a high-quality chemical foundation.

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