Buy Aeruginascin Cas 114264-95-8

Buy Aeruginascin Cas 114264-95-8

Aeruginascin, also known as 4-phosphoryloxy-N,N,N-trimethyltryptamine (4-PO-TMT), is an indoleamine derivative which occurs naturally within the mushrooms Inocybe aeruginascens,^{[1][2][3][4][5][6]} Pholiotina cyanopus,^[6] and Psilocybe cubensis.^[7] It was discovered by Jochen Gartz.^{[8][9][10][11][12]}

The first report about the possible effects of aeruginascin is from a study published by Jochen Gartz in 1989.^[13] Across 23 analyzed cases of accidental hallucinogenic mushroom poisonings, people who had ingested the mushroom Inocybe aeruginascens reported only euphoric experiences.^[14][15] This is in contrast to the slight and in some cases extremely dysphoric experiences reported from the accidental ingestion of non-aeruginascin-containing mushrooms (containing solely psilocybin and psilocin).^[15] However, these findings are anecdotal and preliminary.^[15]

Aeruginascin is the N-trimethyl analogue of psilocybin. It is closely related to the frog skin toxin bufotenidine (5-HTQ), a potent serotonin 5-HT₃ receptor agonist, but the aeruginascin metabolite 4-HO-TMT (thought to be its active form) shows strong binding at the serotonin 5-HT₂ receptors similar to psilocin.^[16][17] Aeruginascin itself has been found to have high affinity for the serotonin 5-HT_1A, 5-HT_2A, and 5-HT_2B receptors, but does not bind to the 5-HT₃ receptor.^[18] Unlike psilocybin, but similarly to 4-HO-TMT, aeruginascin does not produce the head-twitch response in rodents.^[19][20] It lacks affinity or activation of the mouse 5-HT_2A and 5-HT_1A receptors.^[20]

Analogues of aerguinascin include 4-HO-TMT, norbaeocystin (4-PO-T), 4-hydroxytryptamine (4-HT or 4-HO-T), baeocystin (4-PO-NMT), norpsilocin (4-HO-NMT), psilocybin (4-PO-DMT), psilocin (4-HO-DMT), and ethocybin (4-PO-DET), among others.