Buy ALEPH-1 Cas 61638-07-1

Buy ALEPH-1 Cas 61638-07-1

Aleph, or ALEPH-1, also known as DOT or para-DOT or as 4-methylthio-2,5-dimethoxyamphetamine, is a psychedelic drug of the phenethylamine, amphetamine, and DOx families.^[1] It is one of the Aleph series of compounds.^[1]

In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists Aleph’s dose range as 5 to 10 mg orally and its duration as 6 to 8 hours.^[1] The effects of Aleph have been reported to include simple tasks feeling “alien”, intense intellectual stimulation, impairment, a sensation of pleasant physical warmth, and an afterglow including feelings of empathy for everything.^[1]

Aleph is known to be a partial agonist of the serotonin 5-HT_2A receptor (EC₅₀Tooltip half-maximal effective concentration = 10–66 nM; E_maxTooltip maximal efficacy = 114–191%).^[2][3]

It has weak MAO-A inhibitory activity with an IC₅₀Tooltip half-maximal inhibitory concentration of 5.2 μM.^[4] For comparison, amphetamine has an IC₅₀ of 11 μM and 4-methylthioamphetamine (4-MTA) has a value of 0.2 μM.^[4]

The chemical synthesis of Aleph has been described.^[1]

Derivatives of Aleph include Aleph-2, Aleph-4, Aleph-6, and Aleph-7.^[1] The Aleph series of compounds are the DOx or amphetamine analogues of 2C-T, 2C-T-2, 2C-T-4, 2C-T-6, and 2C-T-7, respectively.^[1]

Aleph was first tested by Alexander Shulgin in 1975.^[1] It was first described in the scientific literature by Shulgin and David E. Nichols in 1976.^[5][6] Its properties and effects in humans were described by them in 1978.^[7] Subsequently, the drug was described in greater detail by Shulgin in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).^[1]

Aleph was named by Alexander Shulgin, who named it after the first letter of the Hebrew alphabet.^[1] Another earlier name of the drug is para-DOT.^[1][7]

Aleph is a controlled substance in Canada under phenethylamine blanket-ban language.^[8]

In the United States, Aleph is a Schedule 1 controlled substance as a positional isomer of 2C-T-4 and 2C-T-7.^[9]