Buy BOB Cas 98537-42-9

Buy BOB Cas 98537-42-9

BOB, also known as 4-bromo-2,5,β-trimethoxyphenethylamine or as β-methoxy-2C-B, is a psychedelic drug of the phenethylamine, 2C, and BOx families.^[1] It is the β-methoxy derivative of 2C-B.^[1] BOB was first synthesized by Alexander Shulgin.^[1]

In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists the dose range as 10 to 20 mg orally and its duration as 10 to 20 hours.^[1] BOB produces an altered state of consciousness, tinnitus, a pleasant tingling throughout the body, and a sense of awareness.^[1]

BOB acts as a serotonin 5-HT_2A receptor agonist.^[2] Its affinity (K_i) was found to be 2.0 nM and its EC₅₀Tooltip half-maximal effective concentration was 0.12 nM with an E_maxTooltip maximal efficacy 63%.^[2] Its affinity was 20-fold lower than that of DOB, its activational potency was half that of DOB and its efficacy was slightly higher than that of DOB (63% and 38%, respectively).^[2] 2C-B was said to have comparable affinity as DOB.^[2]

The chemical synthesis of BOB has been described.^[1]

Analogues of BOB include BOH-2C-B (BOHB; β-hydroxy-2C-B), βk-2C-B (β-keto-2C-B), BOD (β-methoxy-2C-D), BOHD (β-hydroxy-2C-D), and β-methyl-2C-B (BMB), among others.^[1]

BOB was first described in the scientific literature by Alexander Shulgin, Peyton Jacob III, and Darrell Lemaire in 1985.^[3] Subsequently, it was described in greater detail by Shulgin in his 1991 book PiHKAL (Phenethylamines I Have Known and Loved).^[1] The drug’s pharmacology was studied by Richard Glennon and colleagues in 2004.^[2]

BOB is a controlled substance in Canada under phenethylamine blanket-ban language.^[4]

This substance is a Class A drug in the Drugs controlled by the UK Misuse of Drugs Act.^[5]

BOB is not an explicitly controlled substance in the United States.^[6] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.