Buy DOB-5-hemiFLY Cas 178557-10-3

Buy DOB-5-hemiFLY Cas 178557-10-3

DOB-5-hemiFLY, also known as bromo-semi-fly (B-SF) or as 5-MeO-7-Br-4-APDB, is a putative serotonergic psychedelic of the phenethylamine, amphetamine, DOx, and benzofuran families related to DOB and DOB-FLY.^[1][2] It is the derivative of DOB in which the methoxy group at the 5 position has been cyclized with the benzene ring to form a dihydrofuran group or benzodihydrofuran ring system.^[1][2] The drug differs from the FLY psychedelics DOB-FLY and Bromo-DragonFLY (DOB-DFLY) in that only one of the methoxy groups has been cyclized rather than both.^[1][2]

The properties and effects of DOB-5-hemiFLY in humans are unknown.^[1]

DOB-5-hemiFLY shows high affinity for the serotonin 5-HT₂ receptors, including for the 5-HT_2A receptor (K_i = 3.1 nM).^{[1][2][3][4][5][6]} Its affinity for this receptor is similar to that of DOB.^[5][6] The drug fully substitutes for LSD in rodent drug discrimination tests and shows high potency in this regard, with potency similar to that of DOB as well.^{[1][2][7][3][4][5][8][6][excessive citations]}

The chemical synthesis of DOB-5-hemiFLY has been described.^[1][5]

Derivatives of DOB-5-hemiFLY include DOB-FLY and Bromo-DragonFLY (DOB-DFLY).^[1][2]

DOB-5-hemiFLY was first described in the scientific literature by David E. Nichols and colleagues in 1991.^[1][2][5] It was included as an entry in Alexander Shulgin‘s 2011 book The Shulgin Index, Volume One: Psychedelic Phenethylamines and Related Compounds.^[1]

DOB-5-hemiFLY is not an explicitly controlled substance in the United States as of 2011.^{[1][needs update]}