Buy Isoproscaline Cas 64778-72-9

Buy Isoproscaline Cas 64778-72-9

Isoproscaline or 4-isopropoxy-3,5-dimethoxyphenethylamine is a psychedelic drug of the phenethylamine and scaline families related to mescaline.^[1] It is closely related to proscaline and was first synthesized by David E. Nichols and colleagues.^[2] The drug is taken orally.^[1]

In his book PiHKAL (Phenethylamines I Have Known and Loved), Alexander Shulgin lists isoproscaline’s dose as 40 to 80 mg orally and its duration as 10 to 16 hours.^[1] The onset was described as slow and about 2 hours and the descent very slow and gradual and starting at about 6 or 7 hours.^[1] The effects of isoproscaline included enhanced emotions, desire to move and dance, feelings of energy flow and freedom in the body, feelings of ecstasy, euphoria, meaningfulness, mental rejuvenation, enhanced sociability and conversation, body load, queasiness, nausea, discomfort, insomnia, and slight next-day irritability.^[1] No visual changes or other sensory effects were mentioned.^[1] Shulgin described isoproscaline as a “completely fascinating phenethylamine”.^[1]

Isoproscaline shows affinity for the serotonin 5-HT₂ receptors and acts as an agonist of the serotonin 5-HT_2A receptor.^[3]

Isoproscaline is in a class of compounds commonly known as phenethylamines, and the full chemical name is 2-(4-isopropoxy-3,5-dimethoxyphenyl)ethanamine.^[1]

The chemical synthesis of isoproscaline has been described.^[1]

Analogues of isoproscaline include mescaline, escaline, proscaline, allylescaline, and methallylescaline, among others.^[1]

Isoproscaline is not a controlled substance in Canada as of 2025.^[4]

In the UK, its highly likely that this compound would be covered by the “phenylethylamine amendment” to the misuse of drugs act likely rendering it a Class A controlled drug.

Isoproscaline is unscheduled in the United States;^[5] however, because of its close similarity in structure and effects to mescaline, possession and sale of isoproscaline may be subject to prosecution under the Federal Analog Act.