Buy Jimscaline Cas 890309-51-0

Buy Jimscaline Cas 890309-51-0

Jimscaline, also known as C-(4,5,6-trimethoxyindan-1-yl)methanamine, is a conformationally-restricted derivative of the cactus-derived psychedelic drug mescaline, which was reported in 2006 by a team at Purdue University led by David E. Nichols. It acts as a potent agonist for the serotonin 5-HT_2A and 5-HT_2C receptors with the more active (R)-enantiomer having an affinity (K_i) of 69 nM at the human serotonin 5-HT_2A receptor, and around three times the potency of mescaline in drug discrimination tests in animals.^[1] This discovery that the side chain of the psychedelic phenethylamines could be constrained to give chiral ligands with increased activity then led to the later development of the highly-potent benzocyclobutene derivative TCB-2.^[2][3] Jimscaline is not a controlled substance in Canada as of 2025.^[4]