Buy Lophophine Cas 23693-38-1

Buy Lophophine Cas 23693-38-1

Lophophine, also known as 2C-MMDA-1, 5-methoxy-MDPEA, or 3-methoxy-4,5-methylenedioxyphenethylamine (MMDPEA or MMDPEA-1), is a psychedelic drug of the methylenedioxyphenethylamine family.^[1][2][3] It is the α–demethylated homologue of MMDA, and is also closely related to mescaline (3,4,5-trimethoxyphenethylamine) and MDPEA.^[1][2] Lophophine has been encountered as a novel designer drug.^[3]

Alexander Shulgin reported in PiHKAL (Phenethylamines I Have Known and Loved) and other publications that lophophine is active in the dose range of 150 to 250 mg orally.^[1][2][3] He states that at these doses, lophophine has some similarity to mescaline in action, in producing a peaceful elevation of mood, euphoria, and mild enhancement of visual perception, but without the generation of closed-eye mental imagery.^[1][2] Shulgin also notes that, in contrast to mescaline, lophophine causes no nausea.^[1][2] He estimated that it was about twice the potency of mescaline.^[1][2]

Lophophine, also known as 3-methoxy-4,5-methylenedioxyphenethylamine, is a phenethylamine and methylenedioxyphenethylamine (MDxx) derivative.^[1][3]

The chemical synthesis of lophophine has been described.^[1]

Analogues of lophophine (5-methoxy-MDPEA or 2C-MMDA-1) include mescaline (3,4,5-trimethoxyphenethylamine), 3,4-methylenedioxyphenethylamine (MDPEA), 2C-MMDA-2 (MMDPEA-2), 2C-MMDA-3a (MMDPEA-3a), and MMDA (5-methoxy-MDA), among others.^[1]

Alexander Shulgin originally suggested that lophophine may be a natural constituent of peyote (Lophophora williamsii) due to it being the only logical chemical intermediate for the biosynthesis of several tetrahydroisoquinolines known to be present in this cactus species.^[1] Subsequently, lophophine was indeed shown to be a minor component of both peyote and San Pedro cactus.^[4]

Lophophine was encountered as a novel designer drug in Europe in 2023.^[3]

Lophophine is controlled substance in Canada under phenethylamine blanket-ban language.^[5]

Lophophine is not an explicitly controlled substance in the United States.^[6] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.