Buy LSM-775 Cas 4314-63-0
Buy LSM-775 Cas 4314-63-0
LSM-775, also known as N-morpholinyllysergamide or as lysergic acid morpholide, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD).[1][3]
Use and effects
LSM-775 is less potent than LSD but is reported to have some LSD-like effects at doses ranging from 75 to 1,000 μg orally and a shorter duration.[1][4][3] It may only produce weak or threshold psychedelic effects in humans.[4] There have been said to be fewer signs of cardiovascular stimulation and peripheral toxicity with LSM-775 compared to LSD.[1] On the other hand, more recent reports suggest that LSM-75 produces considerable nausea and feelings of lethargy and sedation.[4]
Interactions
Pharmacology
Pharmacodynamics
LSM-775 is a potent full agonist of the serotonin 5-HT1A receptor and a potent partial agonist of the serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors.[4] It does not produce the head-twitch response, a behavioral proxy of psychedelic effects, in rodents.[4] However, LSM-775 can robustly increase head twitches if it is coadministered with the serotonin 5-HT1A receptor antagonist WAY-100635.[4] These findings indicate that serotonin 5-HT1A receptor activation suppresses the psychedelic-like effects of LSM-775.[4]
Chemistry
Synthesis
The chemical synthesis of LSM-775 has been described.[1]
Analogues
Analogues of LSM-775 include the cyclized lysergic acid piperidide (LA-Pip), lysergic acid azepane (LA-Azepane), lysergic acid pyrrolidide (LA-Pyr; LPD-824), lysergic acid pyrrolinide (LPN), and lysergic acid 2,4-dimethylazetidide (LA-Az, LSZ) and the non-cyclized LEO, LA-MeO, ergometrine, and methylergometrine, among others.[1][5]
History
LSM-775 was first described in the scientific literature by Albert Hofmann and colleagues by 1955.[4][6] It emerged as a novel designer drug in 2013.[4]
Society and culture
Legal status
Canada
LSM-775 is not a controlled substance in Canada as of 2025.[7]
United States
LSM-775 is not an explicitly controlled substance in the United States.[8] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.
Reviews
There are no reviews yet.