Buy O-Pivalylbufotenine (5-Pivaloxy-N)
Buy O-Pivalylbufotenine (5-Pivaloxy-N)
O-Pivalylbufotenine, or bufotenine O-pivalate, also known as 5-pivaloxy-N,N-dimethyltryptamine (5-t-BuCO-DMT) or as O-pivalyl-N,N-dimethylserotonin, is a synthetic tryptamine derivative and putative serotonergic psychedelic.[1][2][3][4] It is the O–pivalyl analogue of the naturally occurring but peripherally selective serotonergic tryptamine bufotenine (5-hydroxy-N,N-dimethyltrypamine or N,N-dimethylserotonin) and is thought to act as a centrally penetrant prodrug of bufotenine.[1][2][3][4]
Use and effects
Interactions
Pharmacology
O-Pivalylbufotenine is thought to be a prodrug of bufotenin and shows psychedelic-like effects in animal.[3][4] However, it is less active than anticipated, perhaps due to its high lipophilicity and, by extension, high plasma protein binding and ester hydrolysis into bufotenin prior to crossing the blood–brain barrier.[3][4] In addition to theoretically acting as a prodrug of bufotenine, which is a non-selective serotonin receptor agonist,[5][6][7] O-pivalylbufotenine may also interact directly with certain serotonin receptors.[4]
Chemistry
Analogues
Analogues of O-pivalylbufotenine (5-t-BuCO-DMT) include bufotenin (5-HO-DMT), 5-MeO-DMT (mebufotenin), and 4-AcO-DMT (psilacetin), among others. In addition, besides O-pivalylbufotenine, other bufotenine O–acyl esters and putative or confirmed bufotenine prodrugs, such as O-acetylbufotenine among others, have been developed and studied.[1][4]
History
O-Pivalylbufotenine was first described in the scientific literature by 1979.[4]
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