Buy O-Tetramethylserotonin Cas 101831-90-7
Buy O-Tetramethylserotonin Cas 101831-90-7
α,N,N,O-Tetramethylserotonin (α,N,N,O-TeMS), also known as 5-methoxy-α,N,N-trimethyltryptamine (5-MeO-α,N,N-TMT), is a synthetic compound of the tryptamine, α-alkyltryptamine, and 5-methoxytryptamine families.[1][2][3] It is the combined derivative of α-methyltryptamine (αMT) and 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT).[1][2][3]
Use and effects
α,N,N,O-TeMS was described by Alexander Shulgin in his book TiHKAL (Tryptamines I Have Known and Loved) as a putative psychedelic drug.[1] However, Shulgin does not appear to have ever synthesized or assayed it.[1] As such, α,N,N,O-TeMS’s effects, dose, and duration are all unknown.[1]
α,N,N,O-TeMS is the N,N–dimethylated derivative of 5-MeO-αMT (α,O-DMS) and the N-methylated derivative of 5-MeO-α,N-DMT (α,N,O-TMS).[1][2][3] 5-MeO-α,N-DMT is less potent and shorter in duration than 5-MeO-αMT, with 5-MeO-α,N-DMT having a dose range of 10 to 20 mg and a duration of 6 to 8 hours versus 5-MeO-αMT having a dose range of 2.5 to 4.5 mg and a duration of 12 to 18 hours.[1][4] Similarly, α,N-DMT (α,N-dimethyltryptamine) is less potent than αMT, with doses of 50 to 100 mg for α,N-DMT and doses of 15 to 30 mg for αMT.[4] Hence, of potential relevance to α,N,N,O-TeMS, it appears that N-methylation of α-alkyltryptamines may reduce their activity by several-fold.[1][4]
Interactions
Chemistry
Analogues of α,N,N,O-TeMS (N,N-dimethyl-5-MeO-AMT) include α-methyltryptamine (AMT), α,N-DMT (N-methyl-AMT), α,N,N-TMT (N,N-dimethyl-AMT), α-methylserotonin (5-HO-AMT), 5-MeO-AMT (α,O-DMS), and α,N,O-TMS (N-methyl-5-MeO-AMT), among others.[1] Another compound, zalsupindole ((R)-N,N-dimethyl-5-MeO-isoAMT), is a close isotryptamine analogue of α,N,N,O-TeMS.[5]
History
α,N,N,O-TeMS was first described in the literature, specifically in TiHKAL, by 1997.[1] It is known to have been made at Edgewood Arsenal, but the facility never published anything on the compound.[2] α,N,N,O-TeMS does not appear to have been otherwise described in the literature.[2][3]
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