Buy Pruvanserin Cas 443144-26-1
Buy Pruvanserin Cas 443144-26-1
Pruvanserin (INNTooltip International Nonproprietary Name; USANTooltip United States Adopted Name; developmental code names EMD-281,014, LY-2422347) is a selective serotonin 5-HT2A receptor antagonist which was under development by Eli Lilly and Company for the treatment of insomnia.[1][3][4] It was in phase II clinical trials in 2008 but appears to have been discontinued as it is no longer in the company’s development pipeline.[5][6]
Pharmacology
Pharmacodynamics
Pruvanserin acts as a selective serotonin 5-HT2A receptor antagonist. In addition to its sleep-improving properties,[7][8] pruvanserin has also been shown to have antidepressant, anxiolytic, and working memory-enhancing effects in animal studies.[9][10][11]
Pharmacodynamics
The time to peak levels of pruvanserin is 2 to 3 hours, with a range of 2 to 6 hours.[2] The mean elimination half-life of pruvanserin is 8.6 to 9.5 hours, with a range of 3.9 to 12.4 hours.[2] However, its brain serotonin 5-HT2A receptor occupancy lasts much longer, with a half-life of approximately 24 hours.[2]
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