Buy Sulfinalol Cas 66264-77-5

Buy Sulfinalol Cas 66264-77-5

Sulfinalol is a beta adrenergic receptor antagonist.^[1]

The preparation of sulfinalol begins by protection of the phenolic hydroxyl as its benzoate ester. Bromination followed by condensation with 4-(4-methoxyphenyl)butan-2-amine gives the amino ketone 3. Successive catalytic reduction and saponification affords amino alcohol 4. Oxidation of the sulfide to the sulfoxide with a reagent such as metaperiodate gives sulfinalol (5).

The methyl group on a sulfoxide is sufficiently acidic to substitute for phenolic hydroxyl.