Buy Thiobuscaline (TB) Cas 90109-57-2

Buy Thiobuscaline (TB) Cas 90109-57-2

Thiobuscaline (TB), or 4-thiobuscaline (4-TB), also known as 3,5-dimethoxy-4-butylthiophenethylamine, is a psychoactive drug of the phenethylamine and scaline families related to the psychedelic drug mescaline.^[1][2][3] It is the analogue of buscaline in which the butoxy group at the 4 position has been replaced with a butylthio group.^[1][2][3]

In his book PiHKAL (Phenethylamines I Have Known And Loved) and other publications, Alexander Shulgin lists thiobuscaline’s dose range as 60 to 120 mg orally and its duration as about 8 hours.^[1][2][3] The effects of thiobuscaline have been reported to include a “benign and beautiful experience which never quite popped into anything psychedelic”, subtle threshold effects, a vague awareness of something, being in a “wonderful place spiritually” but with “some dark edges”, it being “pleasant, but certainly not psychedelic”, and body discomfort.^[1] No clear hallucinogenic effects were described.^[1] Thiobuscaline is listed as being 4 times more potent as a psychoactive drug than mescaline.^[2][3]

Thiobuscaline produced perpetual threshold psychoactive effects that did not further increase across a wide dose range of 35 to 120 mg orally.^[1] Shulgin described it as “always the simple and ephemeral catalyst of euphoria without substance and without body”.^[1] In addition, he said that it could not easily be classified, for instance as a psychedelic or stimulant.^[1] Instead, Shulgin likened thiobuscaline to Ariadne (4C-D), which he noted had been called an “antidepressant“.^[1] He hypothesized that thiobuscaline might be beneficial for treatment of depression in certain people in the exact same way as Ariadne.^[1]

The chemical synthesis of thiobuscaline has been described.^[1] Analogues of thiobuscaline include 4-thiomescaline, 4-thioescaline, and thioproscaline (4-thioproscaline), among others.^[1][2][3]

Thiobuscaline was first described in the scientific literature by Alexander Shulgin and Peyton Jacob III in 1984.^[4] Subsequently, it was described in greater detail by Shulgin in PiHKAL in 1991.^[1]