Buy Tomscaline Cas 1132076-86-8

Buy Tomscaline Cas 1132076-86-8

Tomscaline is a serotonin 5-HT₂ receptor modulator of the phenethylamine and scaline families related to TCB-2.^[1] It is a cyclized phenethylamine and derivative of the psychedelic drug mescaline where the side chain has been cyclized with the benzene ring to form a benzocyclobutene ring system.^[1]

Tomscaline shows affinity for the serotonin 5-HT_2A, 5-HT_2C, and 5-HT_1A receptors.^[1] Its affinities (K_i) were 111 nM for the serotonin 5-HT_2A receptor, 56 nM for the serotonin 5-HT_2C receptor, and 160 nM for the serotonin 5-HT_1A receptor.^[1] Compared to mescaline, tomscaline showed 3.3-fold higher affinity for the serotonin 5-HT_2A receptor, 6.8-fold higher affinity for the serotonin 5-HT_2C receptor, and 18.4-fold higher affinity for the serotonin 5-HT_1A receptor.^[1] Its functional activities at these serotonin receptors and its effects in animals and humans do not appear to have been studied.^[1]

Analogues of tomscaline include TCB-2, 2CBCB-NBOMe, jimscaline, and bromotomscaline, among others.^[1] Bromotomscaline, which is a derivative of tomscaline, shows dramatically or more than 10-fold higher affinities for the serotonin 5-HT_2A and 5-HT_2C receptors than tomscaline itself.^[1]

Tomscaline was first described in the scientific literature by Daniel Trachsel and colleagues in their 2013 book Phenethylamine: von der Struktur zur Funktion (Phenethylamines: From Structure to Function).^[1] It was originally synthesized and studied by David E. Nichols and colleagues at Purdue University, who provided information about tomscaline to Trachsel and colleagues via personal communication in 2010.^[1]

Tomscaline is not a controlled substance in Canada as of 2025.^[2]