Buy Trichocereine Cas 529-91-9

Buy Trichocereine Cas 529-91-9

Trichocereine, or trichocerine, also known as N,N-dimethyl-3,4,5-trimethoxyphenethylamine or as N,N-dimethylmescaline (MM-M), is a phenethylamine alkaloid that is found in several cacti and other plant species and is closely related to the psychedelic drug mescaline (3,4,5-trimethoxyphenethylamine).^[1][2]

In contrast to mescaline, trichocereine has been found to lack psychoactive effects in humans even at large doses.^[3][4][5][6] F. P. Ludueña assessed trichocereine hydrochloride in the mid-1930s and found that it produced no effects, with the exception of slight gastric heaviness, at doses of up 9 mg/kg orally (630 mg for a 70-kg person) and up to 550 mg parenterally.^{[5][1][3][4][7][2][8]} Vojtĕchovský and Krus assessed trichocereine in the 1960s at doses of up to 800 mg (presumably orally) and found that they were weaker than those of 400 mg mescaline.^[3][9] They also tried 400 mg sublingually and reported that it produced moderate psychedelic effects with a one-hour onset (compared to two hours for mescaline) and a “proportionally shorter” duration than mescaline or a duration of one hour.^[3][4][9] Per Alexander Shulgin however, these psychoactive effects were ill-defined and it was felt that they might have been attributable to anxiety.^[3][4]

Shulgin has noted that Trichocereus terscheckii, which contains trichocereine as its major constituent, is commonly consumed in large amounts by humans and animals as a water source without obvious consequences.^[3][4] It has been noted that N-methylation of psychedelic phenethylamines, for instance Beatrice (N-methyl-DOM), has invariably eliminated their hallucinogenic activity.^[10][6]

Trichocereine showed no activity in the conditioned avoidance test in rodents.^[1][7][11] It has been reported to substitute for mescaline in rodent drug discrimination tests.^[11] Trichocereine at a dose of 50 mg/kg intraperitoneally produced full substitution for mescaline (25 mg/kg) in these tests, whereas it only transiently substituted for mescaline when given intracerebroventricularly.^[11] It produces convulsions in cats and causes marked excitation similar to that induced by amphetamine in rodents.^{[7][8][12][13]}

The chemical synthesis of trichocereine has been described.^[1]

Trichocereine was first reported in the Trichocereus terscheckii cactus in 1935 and was subsequently isolated from Gymnocalycium spp. and Turbinicarpus spp. cacti.^[1][2] Additionally, it has been found in the shrubs Acacia berlandieri and Acacia rigidula.^[1] The compound is the major alkaloid present in Trichocereus terscheckii.^[3][4] It has never been reported in peyote (Lophophora williamsii).^[3][4]

Trichocereine was first described in the scientific literature by F. P. Ludueña by 1935.^[6][1][2]

Trichocereine is not a controlled substance in Canada as of 2025.^[14]

Trichocereine is not an explicitly controlled substance in the United States.^[15][1] However, it could be considered a controlled substance under the Federal Analogue Act if intended for human consumption.