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5F-ADB (also known as MDMB-5F-PINACA using systematic EMCDDA nomenclature[2] and 5F-MDMB-PINACA) is an indazole-based synthetic cannabinoid from the indazole-3-carboxamide family, which has been used as an active ingredient in synthetic cannabis products and has been sold online as a designer drug.[3][4] 5F-ADB is a potent agonist of the CB1 receptor,[5] though it is unclear whether it is selective for this target.
5F-ADB was first identified in November 2014 from post-mortem samples taken from an individual who had died after using a product containing this substance. Subsequent testing identified 5F-ADB to have been present in a total of ten people who had died from unexplained drug overdoses in Japan between September 2014 and December 2014. 5F-ADB is believed to be extremely potent based on the very low levels detected in tissue samples, and appears to be significantly more toxic than earlier synthetic cannabinoid drugs that had previously been sold.[6]
In 2018, 5F-ADB was the most common synthetic cannabinoid to be identified in Drug Enforcement Administration seizures.[7] 5F-ADB was also identified in cannabidiol (CBD) products from a US-based CBD manufacturer in 2018.[8]
Deaths
5F-MDMB-PINACA has been associated with 25 deaths in Europe between 2015 and 2017.[9]
Legal status
In the United States, 5F-ADB is a schedule I controlled substance.[10]
5F-ADB was added to the Japanese banned drug list in December 2014.
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See also
The positional isomer, 4F-MDMB-PINACA has been characterised and is sometimes known as 4F-ADB,[11] despite “ADB” not having been used as a name for MDMB-PINACA. This is distinct from 4F-MDMB-BINACA which is a notable compound in its own right.
- 5F-AB-PINACA
- 5F-AMB
- 5F-APINACA
- AB-CHMINACA
- AB-FUBINACA
- AB-CHFUPYCA
- AB-PINACA
- ADB-BINACA
- ADB-CHMINACA
- ADB-FUBINACA
- ADB-PINACA
- ADBICA
- APICA
- APINACA
- MDMB-CHMICA
- MDMB-FUBINACA
- PX-3
5F-ADB
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Buy 5F-ADB powder for sale online. Also known as 5F-MDMB-PINACA is a very potent, high purity synthetic cannabinoid spice and k2 for research labs with great prices at our RC shop—NNRCHEM. We ship fast globally, overnight in the USA, Canada and EU. No “customs”. With chemical name methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate, 5F-ADB is a synthetic cannabinoid that mimics the effects of naturally occurring cannabinoids found in cannabis. 5F-ADB is primarily used recreationally, often marketed under names like “Spice,” “K2,” or “herbal incense.”
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including its chemical properties, potential effects, legal status, and safety considerations. This comprehensive guide aims to provide an informative overview for those interested in learning more about this synthetic cannabinoid.
What is 5F-ADB (5F-MDMB-PINACA) Powder?
5F-ADB, also known as 5F-MDMB-PINACA, is a synthetic cannabinoid that mimics the effects of naturally occurring cannabinoids found in cannabis. Its chemical structure is similar to other synthetic cannabinoids, featuring a fluorinated adamantyl group, which differentiates it from other compounds in this category. The full chemical name of 5F-ADB is methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate.
Mechanism of Action
Synthetic cannabinoids like 5F-ADB interact with the endocannabinoid system in the human body, specifically binding to CB1 and CB2 receptors. This interaction can produce a range of effects, from euphoria and relaxation to more severe adverse reactions. The potency of 5F-MDMB-PINACA is often higher than that of natural cannabinoids, leading to significant and sometimes unpredictable effects.
Effects of 5F-ADB
Short-Term Effects
The immediate effects of 5F-MDMB-PINACA can vary widely among users, depending on factors such as dosage, individual tolerance, and the method of administration. Common short-term effects include:
– Euphoria
– Altered perception
– Relaxation
– Increased heart rate
– Dry mouth
However, higher doses or prolonged use can lead to more severe reactions, including anxiety, paranoia, and hallucinations.
Long-Term Effects
There is limited research on the long-term effects of 5F-MDMB-PINACA, primarily due to its relatively recent emergence in the market. However, prolonged use of synthetic cannabinoids has been associated with various health risks, such as:
– Cognitive impairment
– Dependence and withdrawal symptoms
– Cardiovascular issues
– Mental health disorders
Legal Status of 5F-ADB (5F-MDMB-PINACA)
The legal status of 5F-MDMB-PINACA varies significantly across different countries. In many jurisdictions, synthetic cannabinoids, including 5F-ADB, are controlled substances due to their potential for abuse and adverse health effects. For instance, the United States classifies 5F-MDMB-PINACA as a Schedule I substance under the Controlled Substances Act, making it illegal to manufacture, distribute, or possess.
Regional Differences
While some countries have comprehensive laws regulating synthetic cannabinoids, others may have less stringent controls. It is crucial for individuals to be aware of the specific regulations in their region to avoid legal complications. For example, in certain European countries, synthetic cannabinoids are regulated under blanket bans, while others may list specific compounds individually.
Safety and Health Considerations
Risks and Adverse Effects
The use of 5F-MDMB-PINACA is associated with several risks and potential adverse effects. Due to its high potency, even small amounts can lead to severe reactions. Common adverse effects reported include:
– Severe anxiety and paranoia
– Respiratory issues
– Cardiovascular problems
– Seizures
In extreme cases, use of 5F-MDMB-PINACA has been linked to fatal overdoses. The lack of standardization in the production of synthetic cannabinoids also increases the risk of contamination with other harmful substances.
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The detection of highly potent indazole-3-carboxamides in complex biological matrices presents a unique analytical bottleneck for modern forensic toxicology laboratories. 5F-ADB (systematically known as 5F-MDMB-PINACA), characterized by its tert-leucine moiety and terminal fluoropentyl chain, requires highly optimized extraction protocols. For analytical chemists and toxicology researchers who need to buy 5f-adb online to establish baseline recovery rates for Solid Phase Extraction (SPE) or Liquid-Liquid Extraction (LLE), securing a reference standard with unassailable purity is a foundational requirement for defensible casework. Buy 5f adb
Table of Contents
Core Physicochemical Reference Parameters
- Target Compound: 5F-ADB (5F-MDMB-PINACA)
- IUPAC Name: Methyl 2-(1-(5-fluoropentyl)-1H-indazole-3-carboxamido)-3,3-dimethylbutanoate
- CAS Registry Number: 1715016-75-3 [[10]]
- Molecular Formula: C20H28FN3O3
- Molar Mass: 389.45 g/mol
- Verified Purity: >= 99.0% (Independent HPLC & GC-MS)
- Physical State: Fine, white to off-white crystalline powder
- Format: Analytical reference unit Buy 5f adb
Matrix Isolation & Metabolite Mapping Challenges
When toxicology labs choose to buy 5f-adb online for panel validation, they are primarily addressing the rapid metabolic clearance of the parent compound. In urine and blood matrices, 5F-ADB undergoes extensive biotransformation, primarily via ester hydrolysis (yielding the M1 metabolite) and tert-butyl hydroxylation. Independent analytical communities, such as those documented on PsychonautWiki and the extensive harm-reduction archives at Erowid, frequently highlight the critical need for a pure parent standard to accurately map the mass shifts and retention time drifts of these major metabolites during LC-MS/MS analysis. Buy 5f adb
Mass Spectrometry Deconvolution & Isobaric Separation
In electron impact (EI) or electrospray ionization (ESI) mass spectrometry, 5F-ADB yields highly diagnostic fragment ions that allow for clean separation from isobaric interferences. The most prominent diagnostic feature is the cleavage of the tert-leucine methyl ester, alongside fragments resulting from the loss of the fluoropentyl chain. This specific spectral fingerprint allows analysts to definitively separate 5F-ADB from closely related analogs like 5F-MDMB-2201 or ADB-FUBINACA, which share similar core scaffolds but exhibit distinct fragmentation pathways. Cross-referencing these laboratory observations with data shared on independent research forums, like Reddit’s r/ResearchChemicals and the Bluelight analytical discussion boards, helps forensic labs proactively refine their screening panels for unexpected metabolic variants. Buy 5f adb
Sourcing Integrity & Analytical Guarantee
Procuring certified reference materials is the primary defense against the rampant structural substitution prevalent in the unregulated research chemical market. By choosing to buy 5f-adb online from ChemNexis Pharma, laboratories secure a material backed by rigorous, transparent quality control. We do not provide generic certificates; every shipment includes a batch-matched Certificate of Analysis (CoA) featuring full HPLC purity integration and complete GC-MS spectral traces, guaranteeing independent verification of identity and purity upon receipt.
Environmental Control & Statutory Compliance
Maintaining the physicochemical stability of complex indazole-3-carboxamides requires strict environmental controls. The reference material must be stored sealed in its original light-resistant, airtight amber glass vial at 2-8°C, rigorously protected from UV exposure and atmospheric moisture to prevent oxidative degradation. Buy 5f adb
COMPLIANCE NOTICE: This material is sold exclusively for laboratory analysis, forensic reference work, and educational collector purposes. It is strictly not intended for human or veterinary consumption. Furthermore, any entity choosing to buy 5f-adb online through our platform explicitly agrees to our terms of service and confirms that all handling will comply with applicable local, state, and federal regulations regarding scheduled substances.
Researcher Frequently Asked Questions
Q: What is the most reliable way to differentiate 5F-ADB from 5F-MDMB-2201 in a routine screen?
A: While both feature a fluoropentyl chain and an amino acid ester, the definitive differentiation relies on the core scaffold and the specific amino acid. 5F-ADB utilizes an indazole core with a tert-leucine methyl ester, whereas 5F-MDMB-2201 utilizes an indole core with a valine methyl ester, resulting in entirely different molecular weights and fragmentation cascades.Buy 5f adb
Q: Why is community discussion relevant to forensic laboratory standards?
A: Independent research forums often serve as early warning systems for emerging structural analogs and unexpected metabolic pathways. Cross-referencing these community observations with official mass spectrometry data helps forensic labs refine their screening panels proactively and cost-effectively.
Q: What documentation accompanies the reference standard?
A: Every order includes a lot-specific Certificate of Analysis (CoA) detailing HPLC integration and spectral data. For baseline comparative research, databases like PubChem serve as excellent supplementary resources for structural validation.
Complementary Reference Standards for Cannabinoid Profiling: Buy 5f adb
Build a defensible, comprehensive screening library by pairing this standard with our other verified SCRA references:
- 5F-MDMB-2201 Analytical Standard
- AB-FUBINACA Analytical Standard
- SGT-78 Analytical Standard
- Synthetic Cannabinoids (NPS) Category Hub
5F-ADB Powder
5F-ADB (5F-MDMB-PINACA) is an extremely potent indazole-based synthetic cannabinoid, often used in receptor binding studies and forensic toxicology research. It is known for its strong agonist activity at both CB1 and CB2 receptors.
Dopechem supplies ≥99% pure crystalline powder, vacuum-sealed for professional laboratory handling.
💡 What is 5F-ADB?
5F-ADB is a synthetic cannabinoid belonging to the indazole-3-carboxamide family. It gained prominence due to its strong psychoactive effects in lab simulations and similarity to MDMB-FUBINACA.
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IUPAC Name: Methyl (S)-2-[1-(5-fluoropentyl)-1H-indazole-3-carboxamido]-3,3-dimethylbutanoate
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CAS Number: 1715016-75-3
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Molecular Formula: C20H28FN3O3
-
Molecular Weight: 377.46 g/mol
-
Appearance: White to beige crystalline powder
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Purity: ≥99% (HPLC Tested)
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Form: Powder
🌟 Key Features
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Powerful CB1 and CB2 agonist
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Laboratory-grade purity ≥99%
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Perfect for receptor binding affinity and toxicological testing
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COA and MSDS available with every batch
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🧪 Research Applications
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CB1/CB2 receptor studies
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Structure-activity relationship (SAR) analysis
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Synthetic cannabinoid behavior modeling
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⚠️ Strictly for licensed laboratory use only. Not for human or animal consumption.
📦 Storage Guidelines
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Store in a cool, dry place at 2–8°C
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Keep sealed and avoid humidity
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Shelf life: 2 years if unopened
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Use proper PPE when handling
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Harm Reduction Strategies
For those who choose to use 5F-MDMB-PINACA, harm reduction strategies can help mitigate some of the risks. These strategies include:
– Starting with a very low dose to assess individual tolerance
– Avoiding mixing with other substances, particularly alcohol or other drugs
– Having a trusted person present during use
– Seeking immediate medical attention if adverse effects occur
Conclusion
5F-ADB (5F-MDMB-PINACA) is a potent synthetic cannabinoid that has gained popularity in recent years. While it can produce effects similar to natural cannabinoids, its high potency and potential for severe adverse reactions make it a substance of concern. Understanding the chemical properties, potential effects, legal status, and safety considerations of 5F-MDMB-PINACA is crucial for making informed decisions.
As with any substance, awareness and education are key. Whether for personal use or academic interest, being informed about the potential risks and legal implications of 5F-MDMB-PINACA is essential. By prioritizing safety and staying informed, individuals can make better choices regarding the use of synthetic cannabinoids.
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Hazard statements: H336-H319-H335
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