Bua 5-MeO-αET Cas 4765-10-0

Bua 5-MeO-αET Cas 4765-10-0

5-MeO-αET, also known as 5-methoxy-α-ethyltryptamine, is a psychoactive drug of the tryptamine and α-alkyltryptamine families.^[1] It reportedly produces psychedelic and stimulant effects.^[1][2]

The dose range of 5-MeO-αET is 50 to 75 mg orally.^{[1][additional citation(s) needed]} 5-MeO-αET produces entactogenic and stimulant effects that can last 4 to 6 hours.^{[citation needed]} However, little information exists on the psychopharmacological effects of this compound, thus considerable variation with regard to dose and effects can be expected.^{[citation needed]}

The pharmacology of 5-MeO-αET has been studied.^[3] It is a weak partial agonist of the serotonin 5-HT_2A receptor, with a binding affinity (K_i) of 4,073 nM, an EC₅₀Tooltip half-maximal effective concentration of 166 nM, and an E_maxTooltip maximal efficacy of 34%.^[3] For comparison, αET showed 14-fold lower affinity for the receptor than 5-MeO-αET and was inactive as an agonist of the receptor.^[3] The individual stereoisomers of 5-MeO-αET and αET were also assessed.^[3]

Analogues of 5-MeO-AET include α-ethyltryptamine (AET), α-methylserotonin (5-HO-AMT), 5-MeO-AMT, 4-methyl-AET, 5-fluoro-AET, 5-EtO-AMT, 5-fluoro-AET, 5-chloro-AET, and 7-methyl-AET, among others.

5-MeO-AET is not a controlled substance in Canada as of 2025.^[4]

5-MeO-αET is unscheduled and uncontrolled in the United States, but possession and sales of 5-MeO-αET could be prosecuted under the Federal Analog Act because of its structural similarities to αET and αMT.^{[citation needed]}