Buy 2C-t-Bu (2C-tBu)

Buy 2C-t-Bu (2C-tBu)

2C-tBu, or 2C-t-Bu, also known as 4-tert-butyl-2,5-dimethoxyphenethylamine, is a serotonin receptor agonist and putative serotonergic psychedelic of the phenethylamine and 2C families.^[1][2]

The active dose of 2C-tBu in humans is >5 mg orally per Daniel Trachsel and its duration is unknown.^[1] Initial tests with 7 mg and with 10 mg (as 5 mg plus 5 mg 2 hours apart) orally produced no psychedelic effects in humans, but instead induced a pronounced and long-lasting tiredness.^[1] It was hypothesized by Daniel Trachsel and colleagues that 2C-tBu might be a serotonin 5-HT_2A receptor antagonist and might thereby be hypnotic,^[1] but it was instead shown to be an agonist in subsequent studies.^[2]

2C-tBu is a potent serotonin 5-HT_2A receptor agonist (K_i = 9.9–35 nM, EC₅₀Tooltip half-maximal effective concentration = 4.2 nM) and also binds to the serotonin 5-HT_2C receptor (K_i = 7–24 nM).^[1][2] The drug produces a robust head-twitch response, a behavioral proxy of psychedelic effects, in rodents.^[2] It also produces hyperlocomotion in rodents.^[2]

Analogues of 2C-tBu include 2C-Bu, 2C-iBu, 2C-sBu, and DOTB, among others.^[1]

2C-tBu was first described in the scientific literature by Daniel Trachsel and colleagues in 2013.^[1]

2C-tBu is a controlled substance in Canada under phenethylamine blanket-ban language.^[3]